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Selank

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin. It is studied in research settings for its effects on anxiety-related behavior models, neurochemical signaling modulation (including GABAergic and monoaminergic systems), and immune regulation pathways. Selank has been investigated for nootropic and stress-modulating properties in experimental and clinical research contexts. For research use only.

10MG | PHYSICIAN USE ONLY

$73.10

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Confirm compounded formula & unique dosing are necessary for the patient

Research Profile

At a Glance

  • Type: Synthetic Heptapeptide (Tuftsin Analog)
  • Also Known As: Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • Length: 7 amino acids
  • Molecular Weight: ~751.9 Da
  • Primary Target: GABAergic signaling pathways; immune modulation pathways
  • Research Focus: Anxiety-model behavior research, cognitive signaling pathways, stress modulation, immune response regulation
  • Regulatory Status: Not FDA-approved; Research Use Only (RUO) outside approved pharmaceutical systems
  • Categories: Recovery & Repair; Immune Support; Anti-Aging Research; Hormone Research

What Research Shows

  • Demonstrates anxiolytic-like activity in animal behavioral models without the sedative or myorelaxant effects commonly observed with benzodiazepines.
  • Influences GABAergic signaling, with research suggesting modulation of GABA receptor expression and related neurochemical pathways.
  • Studied for effects on monoamine neurotransmitter systems, including serotonin and dopamine turnover in preclinical models.
  • Exhibits immunomodulatory properties associated with its tuftsin-derived structure, influencing cytokine signaling pathways.
  • Investigated in clinical research settings for generalized anxiety disorder and stress-related conditions in controlled trials.

Mechanistic Notes

  • GABA system modulation: Alters GABA receptor subunit expression and influences inhibitory neurotransmission in research models.
  • Monoamine pathway interaction: Affects serotonin and dopamine metabolism in preclinical neurochemical studies.
  • Tuftsin lineage: Derived from the immunomodulatory peptide tuftsin, contributing to immune-regulatory signaling effects.
  • Neuroprotective signaling: Demonstrates regulation of brain-derived neurotrophic factor (BDNF) and related pathways in experimental models.
  • Non-benzodiazepine mechanism: Does not bind directly to benzodiazepine sites but produces anxiolytic-like effects through alternative signaling modulation.

What Remains Unknown

  • Long-term safety data outside limited clinical studies
  • Precise receptor binding interactions across central nervous system regions
  • Standardized dosing paradigms across different experimental contexts
  • Translational applicability beyond research settings

Scientific References (Peer-Reviewed Only)

Volkova A, et al. Selank administration affects the expression of some genes involved in GABAergic neurotransmission.
https://pubmed.ncbi.nlm.nih.gov/26924987/

Zozulia AA, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank in the treatment of generalized anxiety disorder and neurasthenia.
https://pubmed.ncbi.nlm.nih.gov/18454096/

Uchakina ON, et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders.
https://pubmed.ncbi.nlm.nih.gov/18577961/

Research Use Only: Our products are supplied exclusively for laboratory, in-vitro, and scientific research purposes. They are not intended for human or animal use of any kind. All information provided is for educational reference only. This material must be handled only by trained, licensed professionals. Our products are not a drug, food, or cosmetic and must not be misused, misbranded, or introduced into the body in any form.

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