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IGF1-LR3

IGF-1 LR3 is a synthetic analog of insulin-like growth factor-1 engineered to extend biological activity by reducing binding to IGF-binding proteins. In research settings, IGF-1 LR3 is studied for its role in cellular growth signaling, protein synthesis pathways, tissue repair models, and metabolic regulation through IGF-1 receptor activation. For research use only.

1MG | PHYSICIAN USE ONLY

$127.50

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Research Profile

At a Glance

  • Type: Synthetic IGF-1 Analog Peptide
  • Also Known As: Long Arg3 IGF-1; LR3-IGF-1
  • Sequence: Modified IGF-1 with arginine substitution at position 3 and N-terminal extension
  • Molecular Weight: ~9,111 Da
  • Primary Target: Insulin-Like Growth Factor-1 Receptor (IGF-1R)
  • Research Focus: Cell growth signaling, protein synthesis pathways, tissue repair models, metabolic regulation, anabolic signaling
  • Regulatory Status: RUO (Research Use Only); not FDA-approved
  • Categories: Hormone Research; Recovery & Repair; Metabolic Research; Anti-Aging Research

What Research Shows

  • Demonstrates prolonged IGF-1 signaling activity compared to native IGF-1 due to reduced affinity for IGF-binding proteins (IGFBPs), resulting in extended receptor engagement in experimental systems.
  • Activates IGF-1 receptor–mediated anabolic pathways, including PI3K/Akt and MAPK signaling cascades involved in cellular growth, differentiation, and survival.
  • Supports protein synthesis and cellular hypertrophy research, as IGF-1 signaling is a central regulator of muscle cell growth and satellite cell activation in preclinical models.
  • Plays a role in tissue repair and regeneration models, with IGF-1 pathways associated with wound healing, connective tissue remodeling, and cellular recovery following injury.
  • Influences metabolic signaling pathways, including glucose uptake and nutrient partitioning, reflecting IGF-1’s close relationship with insulin signaling in experimental contexts.
  • Demonstrates anti-apoptotic signaling effects in cell culture and animal models, as IGF-1R activation promotes cell survival under stress conditions.

Mechanistic Notes

IGF-1 LR3 exerts its biological effects through sustained activation of IGF-1 receptor signaling pathways:

  • Reduced IGFBP binding: Structural modifications decrease sequestration by IGF-binding proteins, increasing bioavailability and receptor interaction time.
  • IGF-1R activation: Binding to IGF-1 receptors triggers downstream PI3K/Akt and MAPK pathways involved in growth, metabolism, and survival signaling.
  • Anabolic signaling: Activation of mTOR-related pathways supports protein synthesis and cellular hypertrophy in muscle and connective tissue models.
  • Cell survival modulation: IGF-1 signaling inhibits pro-apoptotic pathways and supports cellular resilience during metabolic or mechanical stress.
  • Crosstalk with insulin signaling: Overlapping pathways influence glucose transport, nutrient utilization, and metabolic efficiency in research systems.

What Remains Unknown

  • Lack of controlled human clinical trials evaluating IGF-1 LR3 specifically
  • Long-term safety and tissue-specific effects remain uncharacterized
  • Optimal timing and exposure patterns for different tissue models are not standardized
  • Potential differential effects across cell types and developmental stages require further study

Scientific References (Peer-Reviewed Only)

Conlon et al. (1995) — directly examines Long R3 IGF-1 function in vivo, showing physiological responses to LR3 infusion
https://pubmed.ncbi.nlm.nih.gov/7561636/

Assefa et al. — uses IGF-1 LR3 in adipocyte glucose uptake research, illustrating LR3’s enhanced activity vs IGF-1
https://pmc.ncbi.nlm.nih.gov/articles/PMC5750484/

Philippou et al. (2014) — a comprehensive review on optimizing IGF-1 bioactivity (relevant to LR3 design)
https://pmc.ncbi.nlm.nih.gov/articles/PMC4665094

Bailes et al. (2021) — overview of IGF-1/IGF-1R biology that applies directly to LR3 signaling pathways.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7913862/

Research Use Only: Our products are supplied exclusively for laboratory, in-vitro, and scientific research purposes. They are not intended for human or animal use of any kind. All information provided is for educational reference only. This material must be handled only by trained, licensed professionals. Our products are not a drug, food, or cosmetic and must not be misused, misbranded, or introduced into the body in any form.

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