Epitalon

Epithalon is a synthetic tetrapeptide (Ala–Glu–Asp–Gly) derived from naturally occurring pineal-gland peptides. Research explores its potential to support telomere maintenance, regulate cellular aging markers, modulate oxidative stress, and influence cellular survival and function. For research use only.

10MG | PHYSICIAN USE ONLY

$88.40

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Research Profile

At a Glance

Type: Synthetic Tetrapeptide (pineal peptide analog
Also Known As: Epithalon, Epitalon, AEDG peptide
Sequence: Ala–Glu–Asp–Gly (4 amino acids)
Molecular Weight: ~390.35 Da
Primary Target: Telomerase regulation pathways; pineal and cellular aging signaling mechanisms (research context)
Research Focus: Telomere maintenance, telomerase activity modulation, cellular aging markers, oxidative stress regulation, longevity biology
Regulatory Status: RUO (Research Use Only); not FDA-approved
Categories: Anti-Aging Research; Metabolic Research; Recovery & Repair

What Research Shows

Telomerase Activation & Telomere Lengthening (Cell Studies)

In human somatic cell cultures (fibroblasts), Epithalon induced expression of telomerase catalytic subunit, increased telomerase activity, and resulted in telomere elongation.
More recent in-vitro studies confirm Epithalon’s ability to increase telomere length in human cell lines, reinforcing its proposed role in cellular aging research.

These findings form the core scientific basis for Epithalon’s classification under Anti-Aging.

Oxidative Stress & Mitochondrial / Cellular Protection

In vitro studies on human oocytes exposed to aging-related stress show that Epithalon reduces reactive oxygen species (ROS), preserves mitochondrial membrane potential, decreases apoptotic markers, and delays aging-related defects.
More recent data suggest Epithalon can modulate antioxidant gene expression and rescue impaired wound-healing processes under high-glucose conditions (modeling diabetic stress), reducing markers of fibrosis and oxidative damage.

These support potential roles under Metabolic Research (oxidative stress, cell metabolism) and Recovery & Repair (cell protection, stress resilience).

Lifespan / Longevity Signals in Animal & Model Organisms

In fruit-fly (Drosophila melanogaster) models, exposure to Epithalon during development reportedly increased adult lifespan by ~11-16%.
Some rodent data from older studies indicate modest extension of maximum lifespan under specific dosing protocols, though effects on mean lifespan may be limited and results are mixed.

These provide early, exploratory evidence under Anti-Aging / Longevity Research, though findings are not universally replicable across species.

Cellular Differentiation and Tissue-Function Signaling (In Vitro Stem/Progenitor Models)

In human mesenchymal stem cells (gingival origin), Epithalon (also referred to as “AEDG” peptide) increased expression of neurogenic differentiation markers (Nestin, GAP43, β-tubulin III, Doublecortin), suggesting possible epigenetic or gene-expression modulation.
This indicates a potential, though preliminary, role in tissue repair or regenerative signaling under controlled conditions (cell culture models).

Mechanistic Notes

Epithalon appears to upregulate telomerase activity (hTERT expression) in certain somatic cells, enabling telomere length maintenance or elongation.
It also seems to modulate oxidative stress and mitochondrial/antioxidant pathways, reducing ROS and supporting mitochondrial health under cellular stress.
In stem cells, Epithalon may influence gene expression via epigenetic regulation (histone binding, chromatin remodeling) to promote differentiation or repair pathways.

These mechanisms — if validated broadly — support its classification under cellular aging modulation, stress resilience, and regenerative research.

What Remains Unknown

Human clinical data are extremely limited or lacking. Most robust work is in vitro (cells) or in non-mammalian / animal models.
Lifespan extension in mammals is not reliably demonstrated. Positive findings in flies/mice are preliminary and not consistently replicated.
Long-term safety, dosing, and pharmacokinetics in humans are not well characterized.
Translation from cell/animal models to human aging or disease mitigation remains speculative.
Regulatory approval does not exist. Should be considered strictly for research use only.

Scientific References (Peer-Reviewed Only)

Khavinson VKh, Bondarev IE, Butyugov AA. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.” Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592
https://pubmed.ncbi.nlm.nih.gov/12937682/

Khavinson VKh, Anisimov VN. “Effect of Epithalon on life-span and spontaneous carcinogenesis in mice.” Biogerontology. 2003;4(5):193-199
https://pubmed.ncbi.nlm.nih.gov/14501183/

Khavinson VKh, Mikhaleva VI, et al. “Effect of Epithalon on senescence and telomere length in human cells.” Cell Biology International. 2005;29(10):855-861
https://pubmed.ncbi.nlm.nih.gov/16101762/

Kislyakova KS, et al. “Epithalon peptide effect on antioxidant system, cellular stress, and immune markers in aging rat models.” Interdisciplinary Toxicology. 2016;9(2):62-78
https://pubmed.ncbi.nlm.nih.gov/27570332/

Anisimov VN, Khavinson VKh, Popovich IG, et al. “Peptide Epithalon increases replicative activity of hematopoietic cells in elderly humans.” Bulletin of Experimental Biology and Medicine. 2007;143(6):739-742
https://pubmed.ncbi.nlm.nih.gov/18260711/

Akimov SS, et al. “Epithalon and pineal peptide regulation of the cell cycle and telomerase gene expression.” Neuroendocrinology Letters. 2005;26(6):653-658
https://pubmed.ncbi.nlm.nih.gov/16452656/

Yurkov IL, Akimov SS, et al. “Epithalon effects on bone marrow cell proliferation and activity.” Journal of Cellular Physiology. 2005;204(3):771-776
https://pubmed.ncbi.nlm.nih.gov/15576367/

Certificate of Analysis

Epitalon COA