BPC-157

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids derived from a protective protein found in human gastric juice. Research focuses on its potential roles in tissue healing, angiogenesis, growth factor modulation, and anti-inflammatory pathways. Studies have explored effects on musculoskeletal tissues including tendons, ligaments, and muscles, as well as gastrointestinal protection. For research use only.

10MG | PHYSICIAN USE ONLY

$103.70

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Research Profile

At a Glance

Type: Synthetic Pentadecapeptide (15 amino acids)
Also Known As: Body Protection Compound-157, Bepecin
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Weight: 1,419.55 Da
Primary Target: Multiple pathways including VEGF, GHR, FAK-paxillin, nitric oxide system
Research Focus: Tissue healing, angiogenesis, tendon/ligament repair, GI protection
Regulatory Status: RUO (Research Use Only)
Categories: Tissue Repair Research; Musculoskeletal Research; GI Research; Wound Healing

What Research Shows

Demonstrates robust gastrointestinal protection in preclinical models, including reduced ulceration, enhanced intestinal repair, protection against NSAID-induced damage, and improved gut-barrier integrity.
Accelerates musculoskeletal and soft-tissue healing in animal studies, supporting faster recovery of tendons, ligaments, muscle, bone, and injured connective tissue.
Promotes stable angiogenesis and microvascular repair, improving blood-vessel integrity, nitric-oxide signaling, and resilience to ischemia/reperfusion injury.
Exhibits neuroprotective activity in rodent models, including reduced neuronal inflammation, support for peripheral and spinal-cord recovery, and protection against oxidative and dopaminergic stress.
Reduces systemic inflammation and organ injury across multiple experimental systems, including liver, kidney, cardiac, pancreatic, and endothelial models, via cytokine suppression and microvascular stabilization.

Mechanistic Notes

BPC-157’s activity involves multiple interconnected regenerative pathways:

Core Mechanisms

Upregulates vascular endothelial growth factor (VEGF) expression
Activates ERK1/2 signaling pathway for angiogenesis
Increases growth hormone receptor (GHR) expression in fibroblasts
Modulates nitric oxide (NO) system and counteracts endothelin effects
Activates FAK-paxillin pathway for enhanced cell migration

Tissue Healing Effects

Promotes cell migration from tissue explants (dose-dependent)
Enhances cell survival under oxidative stress conditions
Accelerates collagen synthesis and proper fiber organization
Promotes transition from Type III to Type I collagen
Increases granulation tissue formation

Downstream Effects Observed in Research

Improved tensile strength in healing tendons and ligaments
Enhanced functional recovery scores in animal models
Reduced inflammatory markers (leukotrienes, thromboxanes)
Accelerated bone healing in fracture models
Gastroprotective effects and mucosal healing

What Remains Unknown

Precise molecular mechanisms and receptor binding sites
Optimal dosing protocols across different tissue types
Long-term effects and safety profile in larger studies
Full scope of growth factor pathway interactions
Translation of preclinical findings to human applications
All findings are research-only and preliminary.

Scientific References (Peer-Reviewed Only)

Gwyer D, Wragg NM, Wilson SL. J Orthop Res. 2019.
https://pubmed.ncbi.nlm.nih.gov/30915550/

Chang CH, Tsai WC, et al. J Appl Physiol. 2011.
https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00945.2010

Huang T, Zhang K, Sun L, et al. Front Pharmacol. 2018.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6271067/

Sikiric P, Seiwerth S, et al. J Physiol Paris. 1997.
https://pubmed.ncbi.nlm.nih.gov/9403790/

Sikiric P, Seiwerth S, et al. Life Sci. 2018.
https://pubmed.ncbi.nlm.nih.gov/29682749/

Seiwerth S, Brcic L, et al. Curr Pharm Des. 2013.
https://pubmed.ncbi.nlm.nih.gov/25995620/

Certificate of Analysis

BPC-157 1
BPC-157 2